Publications | benoitlab

Chemical genomics reveals targetable programs of human cancers rooted in pluripotency

Orlando L, Benoit YD, Reid JC, Nakanishi M, Boyd AL, García-Rodriguez JL, Tanasijevic B, Doyle M, Luchman A, Restall IJ, Bergin CJ, Masibag AN, Aslostovar L, Lu JD, Laronde S, Collins TJ, Weiss S, Bhatia M.

Cell Chemical Biology. 2023 Jun 16:S2451-9456(23)00158-7. doi:10.1016/j.chembiol.2023.06.004.

PMID: 37379846

Protocol for serial organoid formation assay using primary colorectal cancer tissues to evaluate cancer stem cell activity

Bergin CJ, Benoit YD.

STAR Protocols. 2022 Mar 4;3(1):101218. doi: 10.1016/j.xpro.2022.101218.

PMID: 35265864

Pharmacological targeting of Sam68 functions in colorectal cancer stem cells

Masibag AN, Bergin CJ, Haebe JR, Zouggar A, Shah MS, Sandouka T, Mendes da Silva A, Desrochers FM, Fournier-Morin A, Benoit YD.

iScience. 2021 Nov 14;24(12):103442. doi: 10.1016/j.isci.2021.103442. eCollection 2021 Dec 17.

PMID: 34877499

Emerging role of G9a in cancer stemness and promises as a therapeutic target

Haebe JR, Bergin CJ, Sandouka T, Benoit YD.

Oncogenesis. 2021 Nov 13;10(11):76. doi: 10.1038/s41389-021-00370-7.

PMID: 34775469

Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics

Benoit YD, Mitchell RR, Wang W, Orlando L, Boyd AL, Tanasijevic B, Aslostovar L, Shapovalova Z, Doyle M, Bergin CJ, Vojnits K, Casado FL, Lu JD, Porras DP, García-Rodriguez JL, Russell J, Zouggar A, Masibag AN, Caba C, Koteva K, Kinthada LK, Patel JS, Andres SN, Mogolan J, Collins TJ, Wright GD, Bhatia M.
Cell Chemical Biology. 2021 May 11, doi:https://doi.org/10.1016/j.chembiol.2021.04.014.

Abnormal dopamine receptor signaling allows selective therapeutic targeting of neoplastic progenitors in AML patients

Aslostovar L, Boyd AL, Benoit YD, Di Lu J, Garcia Rodriguez JL, Nakanishi M, Porras DP, Reid JC, Mitchell RR, Leber B, Xenocostas A, Foley R, Bhatia M.

Cell Reports Medicine. 2021 Feb 16;2(2):100202. doi: 10.1016/j.xcrm.2021.100202. PMID: 33665638

G9a controls pluripotent-like identity and tumor-initiating function in human colorectal cancer

Bergin CJ*, Zouggar A*, Haebe JR, Masibag AN, Desrochers FM, Reilley SY, Agrawal G, Benoit YD.
Oncogene. 2020 Dec 15, doi: 10.1038/s41388-020-01591-7. PMID: 33323965

Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer

Zouggar A, Haebe JR, Benoit YD.

Genes. 2020 Jul 16;11(7):808 doi: 10.3390/genes11070808.

Vascular contributions to 16p11.2 deletion autism syndrome in mice

Ouellette J, Toussay X, Comin CH, Costa LDF, Ho M, Lacalle-Aurioles M, Freitas-Andrade M, Liu QY, Leclerc S, Pan Y, Liu Z, Thibodeau JF, Yin M, Carrier M, Morse CJ, Dyken PV, Bergin CJ, Baillet S, Kennedy CR, Tremblay MÈ, Benoit YD, Stanford WL, Burger D, Stewart DJ, Lacoste B..
Nature Neuroscience. 2020 Sep;23(9):1090-1101. doi: 10.1038/s41593-020-0663-1.

PMID: 32661394

G9a is SETting the Stage for Colorectal Oncogenesis

Bergin CJ, and Benoit YD.

Genes. 2020 Jun 4;11(6):616. doi: 10.3390/genes11060616.

HUMAN PLURIPOTENCY IS INITIATED AND PRESERVED BY A UNIQUE SUBSET OF FOUNDER CELLS

Nakanishi M, Mitchell R, Benoit YD, Orlando L, Reid JC, Shimada K, Davidson KC, Shapovalova Z, Collins TJ, Nagy A, Bhatia M.

Cell. 2019 May 2;177(4):910-924.e22. doi: 10.1016/j.cell.2019.03.013.

SAM68 ALLOWS SELECTIVE TARGETING OF HUMAN CANCER STEM CELLS.

Benoit YD, Mitchell RR, Risueño RM, Orlando L, Tanasijevic B, Boyd AL, Aslostovar L, Salci KR, Shapovalova Z, Russell J, Eguchi M, Golubeva D, Graham M, Xenocostas A, Trus MR, Foley R, Leber B, Collins TJ, Bhatia M.
Cell Chem Biol. 2017 Jul 20;24(7):833-844.e9. doi: 10.1016/j.chembiol.2017.05.026. Epub 2017 Jun 22.

ACUTE MYELOID LEUKAEMIA DISRUPTS ENDOGENOUS MYELO-ERYTHROPOIESIS BY COMPROMISING THE ADIPOCYTE BONE MARROW NICHE.

Boyd AL, Reid JC, Salci KR, Aslostovar L, Benoit YD, Shapovalova Z, Nakanishi M, Porras DP, Almakadi M, Campbell CJV, Jackson MF, Ross CA, Foley R, Leber B, Allan DS, Sabloff M, Xenocostas A, Collins TJ, Bhatia M.
Nature Cell Biol. 2017 Nov;19(11):1336-1347. doi: 10.1038/ncb3625. Epub 2017 Oct 16.

LINEAGE-SPECIFIC DIFFERENTIATION IS INFLUENCED BY STATE OF HUMAN PLURIPOTENCY.

Lee JH, Laronde S, Collins TJ, Shapovalova Z, Tanasijevic B, McNicol JD, Fiebig-Comyn A, Benoit YD, Lee JB, Mitchell RR, Bhatia M.

Cell Rep. 2017 Apr 4;19(1):20-35. doi: 10.1016/j.celrep.2017.03.036.

GSK3 DEFICIENCIES IN HEMATOPOIETIC STEM CELLS INITIATE PRE-NEOPLASTIC STATE THAT IS PREDICTIVE OF CLINICAL OUTCOMES OF HUMAN ACUTE LEUKEMIA.

Guezguez B, Almakadi M, Benoit YD, Shapovalova Z, Rahmig S, Fiebig-Comyn A, Casado FL, Tanasijevic B, Bresolin S, Masetti R, Doble BW, Bhatia M.

Cancer Cell. 2016 Jan 11;29(1):61-74. doi: 10.1016/j.ccell.2015.11.012.

SOMATIC TRANSCRIPTOME PRIMING GATES LINEAGE-SPECIFIC DIFFERENTIATION POTENTIAL OF HUMAN-INDUCED PLURIPOTENT STEM CELL STATES.

Lee JH, Lee JB, Shapovalova Z, Fiebig-Comyn A, Mitchell RR, Laronde S, Szabo E, Benoit YD, Bhatia M.

Nat Commun. 2014 Dec 3;5:5605. doi: 10.1038/ncomms6605.

EPIGENETICS IN INTESTINAL EPITHELIAL CELL RENEWAL.

Roostaee A, Benoit YD, Boudjadi S, Beaulieu JF.

J Cell Physiol. 2016 Nov;231(11):2361-7. doi: 10.1002/jcp.25401. Epub 2016 Apr 26. Review. PMID: 27061836

MOLECULAR PATHWAYS: EPIGENETIC MODULATION OF WNT-GLYCOGEN SYNTHASE KINASE-3 SIGNALING TO TARGET HUMAN CANCER STEM CELLS.

Benoit YD, Guezguez B, Boyd AL, Bhatia M.

Clin Cancer Res. 2014 Nov 1;20(21):5372-8. doi: 10.1158/1078-0432.CCR-13-2491. Epub 2014 Jul 8. Review.

PMID: 25006223

INHIBITION OF PRC2 HISTONE METHYLTRANSFERASE ACTIVITY INCREASES TRAIL-MEDIATED APOPTOSIS SENSITIVITY IN HUMAN COLON CANCER CELLS.

Benoit YD, Laursen KB, Witherspoon MS, Lipkin SM, Gudas LJ.

J Cell Physiol. 2013 Apr;228(4):764-72. doi: 10.1002/jcp.24224.

PMID: 23001792

POLYCOMB REPRESSIVE COMPLEX 2 IMPEDES INTESTINAL CELL TERMINAL DIFFERENTIATION.

Benoit YD, Lepage MB, Khalfaoui T, Tremblay E, Basora N, Carrier JC, Gudas LJ, Beaulieu JF.

J Cell Sci. 2012 Jul 15;125(Pt 14):3454-63. doi: 10.1242/jcs.102061. Epub 2012 Mar 30.

PMID: 22467857

COOPERATION BETWEEN HNF-1ALPHA, CDX2, AND GATA-4 IN INITIATING AN ENTEROCYTIC DIFFERENTIATION PROGRAM IN A NORMAL HUMAN INTESTINAL EPITHELIAL PROGENITOR CELL LINE.

Benoit YD, Paré F, Francoeur C, Jean D, Tremblay E, Boudreau F, Escaffit F, Beaulieu JF.

Am J Physiol Gastrointest Liver Physiol. 2010 Apr;298(4):G504-17. doi: 10.1152/ajpgi.00265.2009. Epub 2010 Feb 4.

PMID: 20133952

INTEGRIN ALPHA8BETA1 REGULATES ADHESION, MIGRATION AND PROLIFERATION OF HUMAN INTESTINAL CRYPT CELLS VIA A PREDOMINANT RHOA/ROCK-DEPENDENT MECHANISM.

Benoit YD, Lussier C, Ducharme PA, Sivret S, Schnapp LM, Basora N, Beaulieu JF.

Biol Cell. 2009 Sep 14;101(12):695-708. doi: 10.1042/BC20090060.

PMID: 19527220

BONE MORPHOGENETIC PROTEIN SIGNALING IS ESSENTIAL FOR TERMINAL DIFFERENTIATION OF THE INTESTINAL SECRETORY CELL LINEAGE.

Auclair BA, Benoit YD, Rivard N, Mishina Y, Perreault N.

Gastroenterology. 2007 Sep;133(3):887-96. Epub 2007 Jul 3.PMID: 17678919